Evaluate the following permutation.
\[
{ }_{22} P_{2}
\]

Step 1 ：We are given a permutation problem to solve, where we need to evaluate the permutation of 22 items taken 2 at a time. The permutation is denoted as \({ }_{22} P_{2}\).

Step 2 ：The formula for permutation is given by \(nPr = \frac{n!}{(n-r)!}\), where \(n\) is the total number of items, \(r\) is the number of items to choose, and \(n!\) is the factorial of \(n\).

Step 3 ：In this case, \(n = 22\) and \(r = 2\). So, we need to calculate \({ }_{22} P_{2} = \frac{22!}{(22-2)!}\).

Step 4 ：After calculating, we find that the permutation of 22 items taken 2 at a time is 462.

Step 5 ：Final Answer: The permutation of 22 items taken 2 at a time is \(\boxed{462}\).