How many seven-digit telephone numbers are possible if the first two digits cannot be ones or zeros?
$64,000,000$ telephone numbers

Step 1 ：The problem is asking for the total number of seven-digit telephone numbers possible if the first two digits cannot be ones or zeros.

Step 2 ：The first two digits can be any of the 8 remaining digits (2-9), and the remaining 5 digits can be any of the 10 digits (0-9).

Step 3 ：Therefore, the total number of possible telephone numbers is calculated as \(8 * 8 * 10 * 10 * 10 * 10 * 10\).

Step 4 ：By calculating the above expression, we get the total number of possible telephone numbers as \(64,000,000\).

Step 5 ：Final Answer: The total number of possible seven-digit telephone numbers, if the first two digits cannot be ones or zeros, is \(\boxed{6,400,000}\).