Step 1 :Given the expression $3xy + 12x + 5y + 20$. To factor by grouping, we first need to group the terms in such a way that we can factor out a common factor from each group.
Step 2 :Group the terms as $(3xy + 12x) + (5y + 20)$.
Step 3 :From the first group, factor out $3x$ to get $3x(y + 4)$.
Step 4 :From the second group, factor out $5$ to get $5(y + 4)$.
Step 5 :Both terms have a common factor of $(y + 4)$. So, factor out $(y + 4)$ to get the final factored form of the expression.
Step 6 :The factored form of the expression $3xy + 12x + 5y + 20$ by grouping is \(\boxed{(3x + 5)(y + 4)}\).