Step 1 :The given differential equation is a first order linear differential equation. The general solution to this type of equation is given by \(N(t) = N(0) e^{kt}\), where \(N(0)\) is the initial condition, \(k\) is the rate of growth, and \(t\) is the time. In this case, \(N(0) = 461000\), \(k = 0.039\), and \(t\) is the number of years since 2006.
Step 2 :Substituting the given values into the equation, we get the function that satisfies the equation as \(N(t) = 461000 * e^{0.039t}\).
Step 3 :To estimate the number of patent applications in 2021, we substitute \(t = 15\) (since 2021 is 15 years after 2006) into the equation to get \(N(2021) = 827490.8443799939\). Rounding to the nearest whole number, we get approximately \(\boxed{827491}\) patent applications in 2021.
Step 4 :To estimate the rate of change in the number of patent applications in 2021, we differentiate the function \(N(t)\) with respect to \(t\) to get \(N'(t) = 0.039 * N(t)\). Substituting \(t = 15\) and \(N(15) = 827490.8443799939\) into the equation, we get \(N'(2021) = 32272.14293081976\). Rounding to the nearest whole number, we get approximately \(\boxed{32272}\).