Step 1 :The question is asking to convert a word sentence into a mathematical equation. The sentence is '21% of 43 is what number?'. In mathematical terms, 'of' usually means multiplication, and 'is' usually means equals. So, we can convert this sentence into the equation '21% * 43 = x', where x is the unknown number we are trying to find.
Step 2 :The mathematical equation that represents the sentence '21% of 43 is what number?' is \(\boxed{0.21 * 43 = x}\).