Step 1 :We are testing the claim that less than 9% of treated subjects experienced headaches. The null hypothesis would be that the proportion of subjects who experienced headaches is equal to 9%.
Step 2 :To calculate the P-value, we can use the normal approximation to the binomial distribution. The formula for the z-score is: \[ z = \frac{p - \hat{p}}{\sqrt{\frac{\hat{p}(1-\hat{p})}{n}}} \] where p is the proportion under the null hypothesis (0.09 in this case), \(\hat{p}\) is the observed proportion (15/295), and n is the sample size (295).
Step 3 :Substituting the given values into the formula, we get: p = 0.09, \(\hat{p}\) = 0.05084745762711865, n = 295, z = -2.349789859949005.
Step 4 :Using a standard normal distribution table, we find the P-value corresponding to the calculated z-score. The P-value is 0.009392006201522616.
Step 5 :Final Answer: The P-value is \(\boxed{0.0094}\). The null hypothesis is \(\boxed{H_{0}: p=0.09}\). Since the P-value is less than the significance level of 0.05, we reject the null hypothesis. This suggests that the proportion of subjects who experienced headaches is significantly less than 9%.