$(16+6) \times 12-5$

Step 1 ：First, solve the operation inside the parentheses: \((16+6) = 22\)

Step 2 ：Next, multiply the result by 12: \(22 \times 12 = 264\)

Step 3 ：Finally, subtract 5 from the result: \(264 - 5 = 259\)

Step 4 ：Final Answer: \(\boxed{259}\)